Moxtek has achieved low cost, wafer-scale manufacturing of photonic crystal structures for label-free sensing and microarray based surface enhanced fluorescence applications. Here TiO₂ photonic crystal guided-mode resonance structures are presented, and showed a 7.7 fold average fluorescence enhancement factor when compared to a glass reference slide for assays of Human IgG, IgM, IgA, and streptavidin-biotin.  The structure depicted below also produced a 2.5nm spectral shift upon binding of a self-assembled monolayer, thereby demonstrating the capability for detection of sub-monolayer thicknesses of adsorbates.  

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Moxtek has developed cost effective and reliable methods to obtain uniform wafer scale metallic nanohole array patterned biochips. Here their use as fluorescence enhancing substrates for Cy3 based protein microarrays is demonstrated. The structures, utilizing highly focused and enhanced optical fields, greatly boost the fluorescence SNR, allowing for the detection of antigen concentrations 3+ orders of magnitude lower than current commercial standards.

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