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Photonic Crystal Guided-Mode Resonance Sensors for Optical Diagnostics

Emerging Technology

Moxtek has achieved low cost, wafer-scale manufacturing of photonic crystal structures for label-free sensing and microarray based surface enhanced fluorescence applications. Here TiO2 photonic crystal guided-mode resonance structures are presented, and showed a 7.7 fold average fluorescence enhancement factor when compared to a glass reference slide for assays of Human IgG, IgM, IgA, and streptavidin-biotin.  The structure depicted below also produced a 2.5nm spectral shift upon binding of a self-assembled monolayer, thereby demonstrating the capability for detection of sub-monolayer thicknesses of adsorbates.   Picture1

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